Enduring Consequences of Maternal Separation on the Volume of Parvalbumin Interneurons in the Hippocampus | ||
| Journal of Neurodevelopmental Cognition | ||
| دوره 6، شماره 1، خرداد 2025، صفحه 94-102 اصل مقاله (433.17 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.48308/jncog.2025.239340.1015 | ||
| نویسندگان | ||
| Mozhan Parsa؛ Monireh Mansouri* | ||
| Institute for Cognitive and Brain Sciences, Shahid Beheshti University | ||
| چکیده | ||
| Parvalbumin interneurons (PV-INs) are a subset of GABAergic inhibitory neurons that play a crucial role in regulating cortical and hippocampal circuits. Dysfunction of PV-INs is implicated in neurodevelopmental and psychiatric disorders. Maternal separation (MS) is a well-established rodent paradigm used to study adverse early-life experience and its long-term behavioral effects. MS has been shown to reduce PV-INs expression in different brain regions leading to disrupted cognitive behaviors. This research investigated the long-term effect of the MS on the volume of the PV-INs in the CA1 subregion of the hippocampus in rats. Male rat pups were separated from their mothers for 3 hours daily from postnatal day (PND) 1 to PND 14. After weaning, the animals were maintained in a standard manner until adolescence. At adolescence, brain samples were extracted and the volume of the PV-INs in the CA1 area of the hippocampus was measured using the 3D stereological technique with nucleator method. The results showed that the volume of the PV-INs in the CA1 subregion of the hippocampus in maternally separated rats was significantly smaller (p < 0.05) than the intact rats in adolescence. This study showed that early life adverse experiences can have a persistent effect on the volume of PV-INs in the hippocampus into adolescence and suggests that MS may lead to a disruption of synaptic excitatory inhibitory balance and may be associated with symptoms related to autistic behaviors resulting from MS that have been reported in previous studies. | ||
| کلیدواژهها | ||
| Parvalbumin interneurons volume؛ maternal separation؛ animal model؛ neurodevelopmental disorders | ||
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